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. 2018 May 16;15:37. doi: 10.1186/s12977-018-0420-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Antiviral activities of CAB and BIC against a panel of INSTI-resistant triple mutants that include the well-characterized RAL-resistant double mutant G140S/Q148H plus an additional secondary mutation. The EC₅₀ values were determined using vectors that carry the INSTI-resistant triple mutants in single round infection assays. Error bars represent the standard deviations in the data from independent experiments (n = 4). The EC₅₀ values shown in the figure have a maximum of 100 nM. The EC₅₀ values of RAL and EVG against this entire panel of INSTI-resistant triple mutants were all > 100 nM. The EC₅₀ values of CAB against G140S/Y143R/Q148H and G140S/Q148H/N155H were all > 100 nM