Table 2.
Regional effects relating tau and Aβ to longitudinal rates of atrophy
| Region | Aβ × time interaction |
Tau × time interaction |
Tau × time controlling for Aβ × time |
||||||
|---|---|---|---|---|---|---|---|---|---|
| B | t-value | Adjusted P value | B | t-value | Adjusted P value | B | t-value | Adjusted P value | |
| Banks of the superior temporal sulcus | −0.0039 | −2.84 | .00583 | −0.0109 | −5.15 | .00000 | −0.0109 | −4.06 | .00010 |
| Caudal anterior cingulate cortex | 0.0004 | 0.2709 | .78705 | −0.0049 | −0.85 | .39591 | −0.0052 | −0.89 | .37662 |
| Caudal middle frontal gyrus | −0.0025 | −1.6629 | .10095 | −0.0074 | −1.51 | .13530 | −0.0044 | −0.78 | .43531 |
| Cuneus | 0.0002 | 0.0719 | .94276 | −0.0042 | −0.67 | .50606 | −0.0042 | −0.67 | .50548 |
| Entorhinal cortex | 0.0008 | 0.0928 | .92640 | −0.0209 | −3.09 | .00267 | −0.0269 | −3.61 | .00054 |
| Frontal pole | −0.0006 | −0.2986 | .76560 | 0.0063 | 1.18 | .24033 | 0.0069 | 1.26 | .20816 |
| Fusiform gyrus | −0.0038 | −1.8799 | .06381 | −0.0147 | −3.55 | .00060 | −0.0147 | −2.91 | .00454 |
| Inferior parietal cortex | −0.0021 | −1.8018 | .07619 | −0.013 | −4.18 | .00005 | −0.0147 | −3.85 | .00016 |
| Inferior temporal cortex | −0.001 | −0.6511 | .51701 | −0.0103 | −3.43 | .00085 | −0.0132 | −3.64 | .00040 |
| Insula | −0.0039 | −1.7147 | .09024 | −0.0035 | −0.57 | .56754 | −0.0017 | −0.27 | .79159 |
| Isthmus cingulate | −0.0062 | −2.9631 | .00403 | −0.0191 | −4.02 | .00009 | −0.0158 | −3.06 | .00256 |
| Lateral occipital cortex | −0.0016 | −0.9272 | .35694 | −0.0078 | −2.17 | .03314 | −0.0084 | −1.97 | .05146 |
| Lateral orbitofrontal cortex | −0.0014 | −0.9398 | .35083 | −0.0009 | −0.16 | .87056 | 0.0004 | 0.08 | .93691 |
| Lingual gyrus | −0.0032 | −1.1853 | .23911 | −0.0086 | −1.39 | .16707 | −0.0079 | −1.26 | .21096 |
| Medial orbital frontal cortex | −0.0027 | −1.7311 | .08784 | −0.0123 | −1.90 | .06128 | −0.0114 | −1.76 | .08258 |
| Middle temporal gyrus | −0.0015 | −1.0751 | .28622 | −0.0096 | −3.01 | .00313 | −0.0111 | −2.90 | .00434 |
| Paracentral gyrus | −0.0037 | −1.4636 | .14808 | −0.0035 | −0.49 | .62762 | −0.0019 | −0.27 | .79104 |
| Parahippocampal cortex | −0.0047 | −1.1655 | .24740 | −0.02 | −3.14 | .00233 | −0.0203 | −2.86 | .00519 |
| Pars opercularis | −0.0024 | −1.5936 | .11246 | −0.0138 | −2.32 | .02142 | −0.0128 | −2.13 | .03453 |
| Pars orbitalis | 0.0001 | 0.0628 | .95017 | 0.006 | 1.25 | .21444 | 0.0063 | 1.27 | .20763 |
| Pars triangularis | −0.0004 | −0.3179 | .75076 | −0.0099 | −1.98 | .04832 | −0.0096 | −1.92 | .05556 |
| Pericalcarine cortex | −0.0003 | −0.1267 | .89929 | 0.0026 | 0.31 | .75614 | 0.0027 | 0.32 | .74731 |
| Postcentral gyrus | 0.0006 | 0.2626 | .79360 | −0.0014 | −0.21 | .83138 | −0.0017 | −0.26 | .79910 |
| Posterior cingulate cortex | −0.0024 | −1.9147 | .05899 | −0.0141 | −2.67 | .00874 | −0.012 | −2.05 | .04273 |
| Precentral gyrus | −0.0029 | −0.9078 | .36737 | −0.0087 | −0.84 | .40198 | −0.0068 | −0.64 | .52336 |
| Precuneus cortex | −0.0024 | −2.1989 | .03179 | −0.0098 | −2.11 | .03777 | −0.0067 | −1.30 | .19534 |
| Rostral anterior cingulate cortex | −0.0001 | −0.0734 | .94167 | 0.0017 | 0.25 | .80612 | 0.0017 | 0.25 | .80556 |
| Rostral middle frontal | −0.0008 | −0.6686 | .50571 | −0.0026 | −0.51 | .60828 | −0.0023 | −0.45 | .65569 |
| Superior frontal cortex | −0.0024 | −2.0056 | .04637 | −0.0059 | −1.13 | .26050 | −0.0039 | −0.74 | .45983 |
| Superior parietal cortex | −0.0002 | −0.1315 | .89578 | −0.0022 | −0.47 | .63724 | −0.0024 | −0.44 | .66145 |
| Superior temporal gyrus | −0.0021 | −1.2591 | .21213 | −0.0072 | −1.49 | .13919 | −0.0058 | −1.08 | .28262 |
| Supramarginal gyrus | −0.0014 | −0.9435 | .34642 | −0.0119 | −2.30 | .02254 | −0.0115 | −2.05 | .04189 |
| Temporal pole | 0.0001 | 0.0149 | .98810 | −0.0045 | −0.50 | .61688 | −0.0055 | −0.55 | .58304 |
| Transverse temporal gyrus | −0.0026 | −0.8029 | .42423 | 0.0052 | 0.58 | .56118 | 0.0071 | 0.77 | .44330 |
Abbreviation: Aβ, amyloid β.
NOTE. Bold values represent multiple comparison adjusted P values <.05.