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Voxelwise gray matter and FDG-PET comparisons between amyloid-negative healthy controls (Aβneg HC) and amyloid-negative (Aβneg) and amyloid-positive (Aβpos) amnestic mild cognitive impairment (aMCI) patients. The threshold was set at P uncorrected < .001, k > 50 for MRI, and k > 120 for FDG-PET. Effect sizes are presented in Supplementary Fig. 1. Abbreviations: FDG, 18F-fluorodeoxyglucose; PET, positron emission tomography; MRI, magnetic resonance imaging.
