Table 1.
Benefits of clozapine use in clinical practice (modified from De Berardis et al.10)
| Established effectiveness in treatment-resistant schizophrenia, both in the short and the long term |
| Effective on both positive and negative symptoms of treatment-resistant schizophrenia |
| Effective in improving patients’ functioning and quality of life in treatment-resistant schizophrenia |
| Effective in reducing aggressive behavior, hostility and excitement in schizophrenia |
| Effective in reducing the comorbid use of alcohol and drugs in patients with schizophrenia, possibly by a reduction in craving |
| Effective in reducing suicidality in schizophrenia |
| Efficacious in severe and treatment-resistant mood disorders |
| Efficacious in drug-induced psychosis in Parkinson’s disease, without worsening Parkinsonism |
| Effective in reducing drug-induced tardive dyskinesia |
Clozapine treatment may decrease mortality from natural or disease-related causes in treatment-resistant schizophrenia