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DTI. A, B, Group differences in anatomical connectivity with seed in SN/VTA and targets in (A) VS and (B) vmPFC. C, SN/VTA–hippocampus anatomical connectivity is negatively correlated with lifetime cannabis use. ρ = −0.44*. D, Mean FA in the hippocampus is reduced in DCC+/− carriers. Red circles are DCC+/− carriers, blue circles are DCC+/+ relatives, and green circles are UHVs. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.
