Table 2.

Selected studies of anti-inflammatory treatments in stroke and their respective nuclear imaging readouts.

Drug	Target	Imaging readout	Effect	Reference
Multi-nutrient diet	Broad spectrum	[18F]DPA-714, DTI, rsfMRI	Inflammation ↓, DTI, rsfMRI ↑, functional outcome ↑	54
Minocycline	Broad spectrum	[18F]DPA-714 and [18F]PBR06 PET, MRI	Inflammation ↓, functional outcome ↑	69, 76
sulfasalazine and S-4-CPG	inhibition of system xc	[18F]DPA-714, [18F]FSPG	Inflammation ↓	72
DhβE	α4β2 antagonist	[11C]PK11195 and 2[18F]-fluoro-A85380	Inflammation ↑	77
AMD3100	CXCR4 antagonist	[18F]DPA-714	Inflammation ↓	70