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. 2018 Apr 15;8(10):2846–2861. doi: 10.7150/thno.23463

Figure 2.

Figure 2

AC026904.1 and UCA1 are highly expressed in metastatic breast cancer and predict poor outcome in breast cancer patients. (A-B) Relative RNA levels of AC026904.1 (A) and UCA1 (B) in metastatic and non-metastatic breast cancer (n = 30 per group). Each data point represents an individual breast cancer sample. (C) Representative ISH staining of UCA1 and IHC staining of E-cadherin in normal breast tissue (NB), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). Scale bar: 100 μm. (D) Relative RNA levels of AC026904.1 and UCA1 (mean ± SEM, n = 3) in epithelial-like (MCF7, T47D, and BT-474) and mesenchymal-like (MDA-MB-231, MDA-MB-436, and BT-549) breast cancer cell lines. (E-F) Kaplan-Meier curves representing the probabilities of recurrence-free survival in 60 breast cancer patients stratified according to the expression levels of AC026904.1 (E) and UCA1 (F).