. 2018 May 18;11(5):780–785. doi: 10.18240/ijo.2018.05.10

Table 1. Results of biochemical analysis.

Parameters	C	MTX	MTM	MTME	MTMR	^fP
8-OHdG	0.81 ±0.03^b,c,d	1.57±0.09^a,c,d,e	2.9±0.28^a,b,d,e	2.10±0.14^a,b,c,e	0.92±0.04^b,c,d	0.001
IL-1β	1.65±0.18^b,c,d	2.81±0.24^a,c,d,e	9.18±0.33^a,b,d,e	4.7±0.42 ^a,b,c,e	1.98±0.23^b,c,d	0.001
TNF-α	1.07±0.15^b,c,d	2.16±0.21^a,c,d,e	7.75±0.30^a,b,d,e	4.21±0.27^a,b,c,e	1.63±0.25^b,c,d,e	0.001
MDA	2.65±0.27^b,c,d	3.71±0.54^a,c,d,e	7.98±0.37^a,b,d,e	4.85±0.28^a,b,c,e	3.0±0.31^b,c,d	0.001
MPO	3.20±0.30^b,c,d	6.35±0.56^a,c,d,e	20.33±2.25^a,b,d,e	9.43±0.93^a,b,c,e	3.52±0.54^b,c,d	0.001
tGSH	6.68±0.48^b,c,d	4.21±0.41^a,c,e	1.85±0.18^a,b,d,e	3.73±0.36^a,c,e	6.18±0.45^b,c,d	0.001
SOD	20.0±2.61^b,c,d,e	6.0±0.56^a,c,e	2.88±0.23^a,b,d,e	5.20±0.61^a,c,e	9.95±0.55^a,b,c,d	0.001

C: Controls; MTX: Methotrexate group; MTM: Methotrexate+methanol group; MTME: Methotrexate+methanol+ethanol group; MTMR: Methotrexate+methanol+rutin group; 8-OHdG: 8-hydroxy-2 deoxyguanine; IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-alpha; MPO: Myeloperoxidase; MDA: Malondialdehyde; tGSH: Glutathione peroxidase; SOD: Superoxide dismutase. ^aStatistically significantly different when compared with control group; ^bStatistically significantly different when compared with MTX group; ^cStatistically significantly different when compared with MTM group; ^dStatistically significantly different when compared with MTME group; ^eStatistically significantly different when compared with MTMR group; ^fP value of ANOVA test.