Table 3.

Subgroup analyses of NIHSS, BI, FMA and FIM between the experimental and control groups

Parameter (TP after surgery)	Factors at study level	Experimental group	Control group	Analysis method	Heterogeneity		OR	95% CI	P-value
		No. of patients (n)	No. of patients (n)		I2 (%)	P-value
NIHSS (Month 3)	Cell type
	Auto-MSC	120	119	Random	37	0.18	−2.49	−3.45 to −1.54	<0.00001
	Allo-MSC	50	50	Random			−3.06	−3.82 to −2.30	<0.00001
	Route of delivery
	Subarachnoid	82	77	Random	68	0.04	−3.66	−6.53 to −0.80	0.01
	Intravenous	38	42	Random	0	0.84	−2.30	−3.27 to −1.34	<0.00001
BI (Month 3)	Route of delivery
	Subarachnoid	59	59	Random	6	0.30	4.83	2.66–7.01	<0.0001
	Intravenous	61	84	Random	99	,0.00001	6.02	−10.58 to 22.63	0.48
BI (Month 6)	Cell type
	Auto-MSC	62	80	Random	80	0.002	12.48	3.01–21.94	0.010
	Allo-MSC	60	60	Random			3.70	−1.98 to 9.38	0.20
	Route of delivery
	Subarachnoid	30	30	Random			20.40	9.71–31.09	0.0002
	Intravenous	92	110	Random	72	0.01	7.70	0.96–14.44	0.03
	Patients’ characteristics
	Acute stroke	5	23	Random			25.40	12.95–37.85	<0.0001
	Chronic stroke	27	27	Random	0	0.43	5.19	0.96–9.42	0.02
FMA (Month 3)	Cell type
	Auto-MSC	122	117	Random	97	<0.00001	10.76	2.38–19.14	0.01
	Allo-MSC	110	110	Random	0	0.76	9.04	3.95–14.13	0.0005
	Route of delivery
	Subarachnoid	72	72	Random	99	<0.00001	8.92	−2.73 to 20.58	0.13
	Intravenous	50	45	Random	0	0.38	15.60	12.86–18.35	<0.00001
FIM (Month 3)	Cell type
	Auto-MSC	89	89	Random	84	0.002	17.28	11.01–23.55	<0.00001
	Allo-MSC	78	78	Random	79	0.03	3.19	−5.19 to 11.57	0.46
	Route of delivery
	Subarachnoid	16	16	Random			6.90	−4.80 to 18.60	0.25
	Intravenous	73	73	Random	88	0.004	19.49	13.31–25.66	<0.00001

Abbreviations: TP, time point; OR, odds ratio; NIHSS, National Institutes of Health Stroke Scale; BI, Barthel index; FMA, Fugl-Meyer Assessment; FIM, Functional Independence Measure; auto-MSC, autogenous mesenchymal stem cell; allo-MSC, allogenic mesenchymal stem cell.