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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: Neuroimage. 2014 Oct 12;104:398–412. doi: 10.1016/j.neuroimage.2014.10.002

Table 5.

Hazard rates (HR) of MCI to AD conversion for aggregate biomarker, MRI biomarker and RF with only age and cognitive measures (all methods adjusted for age and gender). Note that the continuous Hazard rate of MRI biomarker is not comparable to other biomarkers because it results from a different classifier (LDS vs. RF) with a different output (Sections MRI biomarker and Aggregate biomarker) and one-unit change has a different meaning.

Aggregate biomarker
MRI biomarker
RF with age & CM
HR 95%CI p HR 95% CI p HR 95% CI p
Continuous 24.63 12.2–49.9 <0.001 2.48 1.9–3.3 <0.001 19.85 10.1–39.1 <0.001
1st vs 2nd quartile   5.14 2.84   2.64
1st vs 3rd quartile   9.16 2.72   5.04
1st vs 4th quartile 10.60 3.52   5.83