Table 7.
Supervised classification of AD conversion prediction using ADNI database. AUC: area under the receiver operating characteristic curve, ACC: accuracy, SEN: sensitivity, SPE: specificity.
| Author | Data | Validation method | Result | Conversion time |
|---|---|---|---|---|
| Moradi et al. (this paper) | MRI, age and cognitive measures | 10-fold cross-validation | AUC = 90% ACC = 82% SEN = 87% SPE = 74% |
0–36 months |
| Misra et al. (2009) | Basic measures and MRI data, 27 pMCI and 76 sMCI |
Leave-one-out cross-validation | AUC = 77% ACC = 75%–80% |
0–36 months |
| Davatzikos et al. (2011) | MRI and CSF, 69 pMCI and 170 sMCI |
k-fold cross-validation | AUC = 73% Max ACC = 62% |
0–36 months |
| Ye et al. (2012) | Basic measures and MRI data, 177 sMCI and 142 pMCI |
Leave-one-out cross-validation | AUC = 86% | 0–48 months |
| Zhang and Shen (2012) | MRI, PET and cognitive scores, 38 pMCI and 50 sMCI |
Leave-one-out cross-validation | AUC = 77% ACC = 78% SEN = 79% SPE = 78% |
0–24 months |
| Gaser et al. (2013) | Age and MRI data, 133 pMCI and 62 sMCI |
Independent test set | AUC = 78% | 0–36 months |
| Cuingnetet al. (2011) | MRI data, 134 sMIC, 76 pMCI |
Independent test set | ACC = 67% SEN = 62% SPE = 69% |
0–18 months |
| Shaffer et al. (2013) | MRI, PET, CSF and basic measurements, 97 MCI | k-fold cross-validation | ACC = 72% | 0–48 months |
| Eskildsen et al. (2013) | Age and MRI data, 161 pMCI, 227 sMCI |
Leave-one-out cross-validation | AUC: pMCI6vs sMCI = 81%, pMCI12 vs sMCI = 76%, pMCI24 vs sMCI = 71%, pMC36 vs sMCI = 64%, |
0–48 months |
| Wolz et al. (2011) | Combination of different MR-based features 238 sMCI, 167 pMCI |
k-fold cross-validation | ACC = 68% SEN = 67% SPE = 69% |
0–48 months |
| Chupin et al. (2009) | MRI data, 134 sMCI, 76 pMCI |
Independent test set | ACC = 64% SEN = 60% SPE = 65% |
0–18 months |
| Cho et al. (2012) | MRI data, 131 sMCI, 72 pMCI |
Independent test set | ACC = 71% SEN = 63% SPE = 76% |
0–18 months |
| Coupé et al. (2012) | MRI data, 238 sMCI, 167 pMCI |
Leave-one-out cross-validation | ACC = 74% SEN = 73% SPE = 74% |
0–48 months |
| Westman et al. (2011a) | MRI data, 256 sMCI, 62 pMCI |
k-fold cross-validation | ACC = 59% SEN = 74% SPE = 56% |
0–12 months |
| Cheng et al. (2012) | MRI, PET, CSF 51 D, 52 NC, 99 MCI Only MRI |
k-fold cross-validation | AUC = 73.6% ACC = 69.4% SEN = 64.3% SPE = 73.5% AUC = 70.0% ACC = 63.3% SEN = 59.8% SPE = 66.0% |
Not available |
| Casanova et al. (2013) | Only cognitive measures, 188 NC, 171 AD, 153 pMCI, 182 sMCI Only MRI (GM) |
k-fold cross-validation | ACC = 65% SEN = 58% SPE = 70% ACC = 62% SEN = 46% SPE = 76% |
0–36 months |