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. 2018 May 17;13(5):e0197513. doi: 10.1371/journal.pone.0197513

Fig 2. RDCRN mitochondrial disease subject validation cohort.

Fig 2

A. Experienced Symptoms. Frequency of experienced symptoms as reported by the RDCRN self-reported cohort revealed muscle weakness, chronic fatigue, exercise intolerance, imbalance, and gastrointestinal problems to be the top 5 common symptoms (n = 290). B. Prioritized Symptoms for trial participation. The RDCRN cohort reported the same top 5 symptoms that would motivate trial participation (n = 290) as seen in the CHOP cohort (Fig 1). C. Likely to participate if experienced symptom is targeted in a clinical trial. The RDCRN cohort reported muscle weakness, chronic fatigue, exercise intolerance, diabetes and kidney disease as the most common experienced and desirable to treat symptoms in a clinical trial (n = 290).