Table 1.

Human diseases in which endothelin-1 may be implicated

Airway diseases

Asthma

Chronic obstructive pulmonary disease

Bronchiectasis

Bronchiolitis obliterans

Parenchymal lung diseases

Pulmonary fibrosis

Idiopathic

Connective tissue associated

Neoplastic diseases

Lung malignancies

Metastases to lung

Pulmonary vascular diseases

Primary pulmonary hypertension

Secondary pulmonary hypertension

Connective tissue diseases

Congenital heart disease

Acute lung injury

Ischemia/reperfusion

Pulmonary edema

Acute respiratory distress syndrome

Sepsis

Lung transplant rejection

Acute: ischemia/reperfusion injury

Chronic: bronchiolitis obliterans