Table 3. Hazard ratios for Cox models with follow-up starting at round 3.
| Death from CHD | ||
|---|---|---|
| GDF-15 | HR per IQR increase (95% CI) | p-value |
| round 3 | 1.99 (1.57, 2.53) | <0.001 |
| delta round 3—round 1 | 1.01 (0.85, 1.2) | 0.93 |
| delta round 3—round 2 | 1.03 (0.83, 1.29) | 0.76 |
| CRP | ||
| round 3 | 1.66 (1.31, 2.12) | <0.001 |
| delta round 3—round 1 | 0.95 (0.77, 1.16) | 0.61 |
| delta round 3—round 2 | 0.93 (0.73, 1.19) | 0.58 |
| Cystatin C | ||
| round 3 | 1.5 (1.23, 1.83) | <0.001 |
| delta round 3—round 1 | 0.91 (0.79, 1.05) | 0.18 |
| delta round 3—round 2 | 1.25 (1.1, 1.43) | <0.001 |
| HF | ||
| GDF-15 | ||
| round 3 | 1.74 (1.38, 2.29 | <0.001 |
| delta round 3—round 1 | 1.16 (0.99, 1.36) | 0.066 |
| delta round 3—round 2 | 1.21 (0.97, 1.5) | 0.085 |
| CRP | ||
| round 3 | 1.43 (1.14, 1.8) | 0.0023 |
| delta round 3—round 1 | 0.83 (0.69, 0.99) | 0.043 |
| delta round 3—round 2 | 0.85 (0.7, 1.05) | 0.13 |
| Cystatin C | ||
| round 3 | 1.1 (0.89, 1.36) | 0.37 |
| delta round 3—round 1 | 1.06 (0.93, 1.2) | 0.40 |
| delta round 3—round 2 | 1.09 (0.91, 1.29) | 0.35 |
Hazard ratios are presented for the round 3 measurement of GDF-15, CRP and Cystatin C and for the differences (delta) between rounds 3 and 1 and round 3 and 2. GDF-15, CRP and Cystatin C included used after log-transformation. The models adjusted for age, sex, overweight (BMI > 25 kg/m2), systolic blood pressure, diabetes, daily smoker and renal insufficiency (eGFR > 60 ml/min or 1.73m3). The models including a delta are additionally adjusted for the corresponding marker round 3 measurement. By “delta round 3 –round i”, i = 1 or 2, it is meant the (absolute) difference of the marker values at rounds 3 and i, that is, marker value at round 3 minus marker value at round i.