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. 2018 May 7;14(5):e1007380. doi: 10.1371/journal.pgen.1007380

Fig 6. CAR inhibition blocks cancer progression in Mdr2-KO livers.

Fig 6

Nodules from HCC livers of Mdr2-/- mice vehicle (UT) or CAR inhibitor treated (T) (50 mg/kg) were measured by caliper, collected for histological analysis and for RT-QPCR expression (see also S10 Table). (A) Q-PCR analysis of representative CAR target genes (UT, nodule number = 22; T, nodule number = 12). (B) Total number of lesions per mouse. (C) Total number of carcinomas per mouse. The central black bars indicate the median. (D) Tumor content measured as a percentage of HCC in each nodule. The number of nodules in the two groups are reported in parentheses. (E) Size differences in nodules from treated and untreated Mdr2-/- mouse groups. In all analyses, differences were assessed using one-sided Mann-Whitney test (p < 0.05).