Fig 2. Cd2ap deficiency has a minimal impact on T_FH differentiation and GC B cell responses following immunization with SRBCs.

(A, B) Flow cytometric analysis of expression of PD-1 and CXCR5 on pre-gated CD4⁺ B220⁻ T cells (A) and GL7 and Fas expression on CD19⁺ B220⁺ B Cells (B) 12 days following SRBC immunization. (C-E) Numbers and frequencies of total CD4 T cells and CXCR5⁺ PD-1⁺ T_FH in the spleen of Cd4-cre⁺ Cd2ap^F/F and control Cd2ap^F/F mice 12 days after immunization with SRBCs. (F-H) Numbers and frequencies of total B cells and Fas⁺ GL7⁺ GC B cells in the spleen of Cd4-cre⁺ Cd2ap^F/F and control Cd2ap^F/F mice 12 days after immunization with SRBCs. Data are pooled from 2 independent experiments shown as means and standard deviation.