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. 2018 May 7;14(5):e1007053. doi: 10.1371/journal.ppat.1007053

Fig 6. Cin85-Deficiency results in defective clearance of LCMV-c13 and is correlated with decreased neutralizing antibody titer.

Fig 6

(A, B) Analysis of LCMV abundance in plasma in Cin85F/F and Cd4-cre+ Cin85F/F mice as determined by LCMV gp transcript levels (A) or focus forming assay (B) at day 80. Horizontal lines indicate median. The limit of detection is shown by dashed lines. Statistical significance was tested by Mann Whitney U-test. (C) Frequencies of Fas+ GL7+ B220+ GC B cells at day 35 after LCMV-c13 infection. (D) anti-LCMV IgG antibody titers of plasma from Cin85F/F and Cd4-cre+ Cin85F/F mice 30 days after LCMV-c13 infection. (E) Neutralizing activity of plasma from Cd2apF/F and Cd4-cre+ Cd2apF/F mice 80 days after LCMV-c13 infection. Reduction in focus forming units (FFU) in the presence of 1:5 dilution of plasma compared to untreated control (% Neutralization) is shown with mean and standard deviation. Student t-test. Data combined from 3 independent experiments are shown with n = 3–4 mice per genotype.