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. 2018 Apr 12;61(9):4135–4154. doi: 10.1021/acs.jmedchem.8b00210

Scheme 4. Synthesis of Methylaminoaryl Substituted Analogues.

Scheme 4

Reagents (a) Pd(PPh4)Cl2, K2CO3, DME, H2O, 90°; (b) DCM, TFA 1:1.