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. 2018 Apr 12;61(9):4135–4154. doi: 10.1021/acs.jmedchem.8b00210

Table 3. Equilibrium Binding Constants for Methylamino Analogues.

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ID R SPR KD [μM]
13 3′-CH2NMe2 4.52 ± 1.36
15a 2′-CH2NH2 1.87 ± 0.32
15b 3′-CH2NH2 2.44 ± 0.71
1 4′-CH2NH2 1.32 ± 0.08
18a 2′,3′-(CH2NHCH2) 2.47 ± 0.25
18b 3′,4′-(CH2NHCH2) 2.17 ± 0.32