Table 3. Equilibrium Binding Constants for Methylamino Analogues.
ID | R | SPR KD [μM] |
---|---|---|
13 | 3′-CH2NMe2 | 4.52 ± 1.36 |
15a | 2′-CH2NH2 | 1.87 ± 0.32 |
15b | 3′-CH2NH2 | 2.44 ± 0.71 |
1 | 4′-CH2NH2 | 1.32 ± 0.08 |
18a | 2′,3′-(CH2NHCH2) | 2.47 ± 0.25 |
18b | 3′,4′-(CH2NHCH2) | 2.17 ± 0.32 |