Figure 4. The Architecture of the Selectivity Filter Is Conserved in Human Ca_v Channels.

(A) Structural side view of 3 repeats in the human model of Ca_v1.1 shows the conservation in space of the amino acids that compose the 3 selectivity rings initially described for the Ca_vAb-engineered channel, as depicted by the ribbon and stick representation of the subunits.

(B) In the multiple sequence alignment, we observe that the residues involved in the selectivity filter sites: 1, 2, and 3, initially described for Ca_vAb, are conserved in all human Ca_v channels with varying amino acids participating in each site.

See also Figure S3.