Table 3.

Modeling Errors in Recent VGIC VSD Cryo-EM-Based Models

PDB Code	Resolution (Å)	Repeat I	Repeat II	Repeat III	Repeat IV
3JBR	4.2	C-term translation: S3 (2 pos.)	N-term translation	N-term translation	errors in side-chain angles (16° difference)
			S2 (7 pos.);	S2 (7 pos.);
			S3 (5 pos.)	S3 (5 pos.)
5GJV	3.6	C-term translation: S3 (5 pos.)	no errors	C-term translation: S3 (3 pos.)	no errors
5X0M	3.8	no errors	no errors	no errors	no errors

Listed in this table are the direction and magnitude of frameshift molecular modeling errors of recent cryo-EM-based models of VGIC; PDB: 3JBR, 5GJV, and 5X0M. For each repeat in the tetrameric subunit, the inaccuracies in residue assignment are described for S2 and S3 of the VSD in the structural models. This table also lists the resolution of the cryo-EM map to emphasize that the modeling errors are exclusive to low-quality maps, as determined by resolution. C-term, C terminus; N-term, N terminus; pos., positions. See also Figure 2.