Table 2.
Bacteriostatic and hemolytic activities of antimicrobials.
| Peptoid | MIC[μgmL−1][a] | HC10[μgmL−1][b] | SI[c] | Reference |
|---|---|---|---|---|
| C1 | 500 | 250 | 0.5 | This study |
| C2 | 3.9 | 125 | 32 | This study |
| C3 | 3.9 | N/D | N/D | This study |
| C4 | 3.9 | 31.3 | 8 | This study |
| C5 | 3.9 | 31.3 | 8 | This study |
| C1dec | 7.8 | 250 | 32 | This study |
| AMPs | ||||
| Gramicidin S | 15.6 | >15.6 | >1 | This study |
| LL-37 | 32 | 167.5 | 5.2 | [74, 75] |
| Melittin | 0.78 | 1.78 | 2.3 | [68, 76] |
| lipopeptides | ||||
| Daptomycin | 16 | >400 | >25 | [71, 73] |
| Polymyxin B | 8-64 | >40 | 0.65-5 | [70, 72] |
| β-lactam antibiotics | ||||
| Penicillin[d] | 128 | >4 | >0.03 | [69] |
[a]
Minimum inhibitory concentrations against methicillin-resistant Staphylococcus aureus (MRSA) USA300.
[b]
Concentrations at which 10% of hemolysis is observed.
[c]
Selectivity index: HC10/MIC against MRSA USA300.
[d]
Penicillin V (phenoxymethylpenicillin).