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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: Mol Cell. 2017 Jun 6;67(1):139–147.e2. doi: 10.1016/j.molcel.2017.04.019

Figure 4. Structural differences between WT AsCpf1 and AsCpf1 variants.

Figure 4

(A) Conformational differences in the PAM duplexes in the structures of WT AsCpf1 (PDB: 5B43) (stereo view).

(B) Structural differences in Arg542 (S542R) between the RVR and RR variants (stereo view).

(C) Structural rearrangements around Arg552 (N552R) in the RVR variant (stereo view). A water molecule is shown as a sphere. In (A)–(C), WT AsCpf1 and the RVR and RR variants are colored gray, orange and purple, respectively.

See also Figure S4.