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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: Anal Chem. 2018 Jan 17;90(3):2178–2185. doi: 10.1021/acs.analchem.7b04515

Figure 6.

Figure 6

Crystal structures of StXPB2 reveal a much more flexible interdomain linker between the two helicase domains. (a) Two StXPB2 molecules are observed in the crystal: One is in gray and the other is colored as helicase domains in green, the damage recognition domain (DRD) is in blue and the thumb-like motif (ThM) domain colored purple. (b) Structural comparison of AfXPB and StXPB2. Center: AfXPB structure is superimposed with the two StXPB2 structures over the DRD and helicase domain1 (gray). The C-terminal halves are shown as indicated colors. The closed conformation is a computational model and ATP-binding groove is highlighted.