Extended Data Table 1.

Fenethylline binding to CNS targets.

Target	Inhib. (%)*	Target	Inhib. (%)*
AdenosineA2A	−5	Muscarinic M2	−6
Adenosine A1	0	Muscarinic M3	2
Adrenergic α2A	16	Nicotinic Ach	2
Adrenergic α1A	27	Nicotinic Ach α1	9
Adrenergic α1B	16	Mu Opiate	7
Adrenergic β2	3	Phorbol Ester	9
Adrenergic β1	9	K ATP Channel	21
L-Type Ca Channel	6	hERG K Channel	−4
Cannabinoid CB1	16	Prostanoid EP4	3
Dopamine D2S	1	Rolipram	9
Dopamine D1	8	Serotonin 5-HT2B	23
GABAA – Site 1	0	Sigma σ1	7
GABAA – Site 2	5	Na Channel – Site 2	−4
Glutamate – NMDA	10	Norepi. Transporter	10
Histamine H1	12	Dop. Transporter	9
Imidazoline I2	4

^*Radioligand displacement measured in the presence of 10 μM fenethylline using the method of Eurofins Cerep Panlabs. Data shown as the average of two replicates.