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. 2018 May 17;8:7806. doi: 10.1038/s41598-018-26112-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Selection of histone modification and DNase peak enrichment analysis results. The enrichment analyses compared 106 SNPs in replicated 3-SNP haplotypes to nominally associated single SNPs in gene regions. Figure shows enrichment test p-values that are log-transformed (-log₁₀(P)) for the 15 blood/liver cell types for which haplotype SNPs are significantly enriched for both H3K4me1 and H3K4me3 peaks. Dashed and dotted vertical lines show Bonferroni-corrected p-value thresholds based on the number of blood/liver cell types for which Roadpmap Epigenomics assay data was available (29 and 11 types for histone mark and DNase peaks, respectively).