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. 2018 May 17;8:7792. doi: 10.1038/s41598-018-26096-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Example spectra from nine voxels with (black) and without (blue) L2-based lipid suppression inside the region of interest marked on the single-slice image (5 × 5 × 10 mm). (b) Metabolite ratio distribution maps of NAA:tCr, Glx:tCr, and tCho:tCr are shown. One coronal slice (Glx:tCr) is shown to demonstrate the through plane resolution as well as the voxel level specificity of white- and gray- matter distribution. Images are shown in neurological orientation (left hemisphere on left side of the image).