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. 2018 May 17;9:1977. doi: 10.1038/s41467-018-04398-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Disproportionate effects on early vs. late puberty for rs10119582 at the PTPRD locus. a Regional association plot for the early puberty model in Japanese. b Effect of rs10119582 at the PTPRD locus on risk of specific ages at menarche. Each point represents the natural log of the odds ratio per +1 ‘T’ allele at rs10119582 for being in that menarche age category compared to the reference group (menarche at age 14 years). Error bars represent the 95% confidence intervals around this estimate. *P = 0.02, **P = 0.004, ***P = 6.4 × 10⁻⁷, ****P = 1.3 × 10⁻¹⁰