Table 2.

Summary of Receptor-like protein tyrosine phosphatase (PTPR) genes implicated in the regulation of puberty through Japanese and European genome-wide association studies (GWAS) for age at menarche, and pre- and peri-pubertal changes in hypothalamic gene expression

PTPR sub-type	Genesa	GWAS	Expression-up	Expression-down
I	C		C
IIA	D,F,S	D,F,S		D,S
IIB	K,M,U,T	K	M	K,T
III	B,H,J,O,Q	J	B,J	O
IV	A,E
V	G,Z1	G,Z1		G,Z1
VI	R
VII	N,N2	N2	N,N2

^aGene names are abbreviated from PTPR*, where * is a letter (or letter/number)