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. 2018 May 17;8:7799. doi: 10.1038/s41598-018-26088-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NTG-A-009 reduces Th1 and Th17 cells differentiation through the inhibition of JAK/STAT pathway. (a) Naïve CD4⁺ T cells isolated from spleen and lympnodes were cultured with or without NTG-A-009 under Th1 condition and re stimulated with anti-CD3 (1 μg/ml) and anti-CD28(1 μg/ml) followed by the analysis of the expression of indicated proteins in JAK/STAT pathway by western blot. Phosphorylated and total form of STAT1, STAT4, and JAK1/2 were analyzed by immunoblotting under Th1 condition. (b) Phosphorylated and total form of STAT3 and JAK1/2 were detected by immunoblotting under Th17 condition. Full length blots and gels were shown in supplementary information- 7, 8, 9 and 10. Data are the representative of three independent experiments.