Fig. 4.

Lymphatic injury results in upregulation of adhesion molecules and chemokines in lymphedematous skin. Mice killed 6 weeks after tail skin and lymphatic excision (lymphedema) or sham surgery (control). a, b Representative immunofluorescent images of venules (a) and LYVE-1⁺ lymphatic vessels (b) in tail cross-sections with localization of E-selectin (top), ICAM-1 (middle), and VCAM-1 (bottom); scale bars, 50 and 30 µm, respectively. c, d Representative immunofluorescent images of tail cross-sections co-localizing LYVE-1⁺ lymphatic vessels with CCL17 (c) and CCL27 (d); scale bars, 100 µm