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Conceptual model of the interplay between the stress system and obesity. Various individual characteristics are proposed to play a role in initiating a vicious circle of increased activation of the stress system (both by perceived chronic stress as well as increased net glucocorticoid effect by either endogenous or exogenous GCs) and obesity in a bidirectional manner. Abbreviations: GC, glucocorticoid; SNP, single nucleotide polymorphism; OSA, obstructive sleep apnea
