Table 1.

Results summary. SRCL sinus rhythm cycle length, hRA-CSos intraatrial conduction time, hRA-CSd interatrial conducion time, RA-ERP right atrium refractory period, LA-ERP left atrium refractory, AVN-ERP atrioventricular node refractory period, WP Wenckebach point, SNRT sinus node recovery period, BPsys systolic blood pressure, BPdias diastolic blood pressure

	Baseline	100 mg	P	200 mg	P	300 mg	P
SRCL (ms)	772.8 ± 38.47	703.4 ± 32.51	< 0.01	703.5 ± 31.03	< 0.05	702.9 ± 31.31	< 0.01
AH (ms)	90.26 ± 5.28	93.93 ± 6.47	ns	96.06 ± 6.34	ns	97.13 ± 5.59	ns
HV (ms)	49.3 ± 2.22	54 ± 3.09	ns	56.46 ± 2.89	< 0.001	58.53 ± 2.89	< 0.001
QRS (ms)	91.93 ± 4.84	95.13 ± 5.64	ns	99.27 ± 6.43	< 0.01	102.73 ± 6.21	< 0.001
QT (ms)	356 ± 7.54	363.33 ± 7.87	ns	363.33 ± 7.29	ns	369.13 ± 7.20	< 0.001
QTc (ms)	408.07 ± 38.18	434.67 ± 9.89	< 0.05	435.73 ± 20.51	< 0.01	443 ± 3.53	< 0.001
hRA-Csos (ms)	83.2 ± 5.39	87.87 ± 5.68	ns	91.4 ± 5.1	< 0.01	93.13 ± 5.67	< 0.001
hRA-CSd (ms)	117.13 ± 6.75	122.8 ± 7.13	ns	126.67 ± 6.64	< 0.001	129.73 ± 7.15	< 0.001
AVN-ERP (ms)	290.67 ± 20.15	298.67 ± 18.97	ns	278 ± 18.24	ns	252 ± 22.39	ns
RA-ERP (ms)	210.67 ± 7.27	232 ± 6.77	ns	239.33 ± 8.31	< 0.05	246.67 ± 8.71	< 0.001
LA-ERP (ms)	230.67 ± 4.52	236.67 ± 4.65	ns	243.33 ± 4.75	< 0.05	246 ± 5.84	< 0.01
WP (bpm)	169.53 ± 6.99	168.73 ± 7.49	ns	168.2 ± 7.71	ns	168.2 ± 7.63	ns
SNRT (ms)	924.2 ± 47.55	N/A		N/A		899.53 ± 40.60	ns
BPsys (mmHg)	123.46 ± 15.55	N/A		N/A		120.47 ± 13.43	ns
BPdias (mmHg)	71.33 ± 17.67	N/A		N/A		73 ± 15.55	ns

N/A not available, ns not significant