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. 2018 May 11;9:471. doi: 10.3389/fphar.2018.00471

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Copyright © 2018 Srivastava, Cornicelli, Markham and Bisgaier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy of reference agents in the collagen antibody-induced joint swelling and arthritis mouse model. Methotrexate (4 mg/kg), cyclosporine A, and anti-TNF-α antibody (83.33 μg) were evaluated in this study. BALB/c mice (n = 5) were administered by oral gavage (methotrexate and cyclosporine) or intraperitoneal injection (anti-TNF-α antibody). The details are provided in the “Materials and Methods” section. The results of day 9 treatment are only shown. Data presented show changes in the footpad and ankle swelling and are expressed as mean ± SEM. ^∗Significantly different compared to vehicle control.