Table 1.
Demographics of FEDN, chronic patients with schizophrenia and healthy controls.
| FEDN(n = 69) | Chronic patients (n = 87) | Healthy controls (n = 61) | χ2 orF | df | P-value | |
|---|---|---|---|---|---|---|
| Sex(M/F) | 46/23 | 44/43 | 31/30 | 0.087 | 2 | 0.087 |
| Age(years) | 25.8 ± 5.9 | 32.9 ± 7.1 | 29.5 ± 6.7 | 22.0 | 2 | < 0.001** |
| Education(years) | 10.5 ± 2.9 | 11.0 ± 3.1 | 12.1 ± 2.6 | 5.2 | 2 | 0.006** |
| Course of disease(years) | 0.8 ± 0.2 | 6.8 ± 1.4 | 55.0 | 154 | < 0.001** | |
| PANSS total score | 84.9 ± 11.2 | 78.5 ± 7.1 | 18.9 | 154 | < 0.001** | |
| P subscore | 18.2 ± 4.3 | 14.9 ± 2.6 | 37.4 | 154 | < 0.001** | |
| N subscore | 25.6 ± 3.8 | 26.2 ± 3.0 | 5.0 | 154 | 0.241 | |
| G subscore | 41.7 ± 7.6 | 37.4 ± 3.8 | 31.1 | 154 | < 0.001** | |
| SANS score | 58.7 ± 13.5 | 64.7 ± 9.8 | 9.7 | 154 | < 0.001** | |
| CGI | 5.5 ± 1.2 | 4.3 ± 0.8 | 15.9 | 154 | < 0.001** | |
| IL-1β(pg/ml) | 1.7 ± 0.2 | 19.3 ± 11.3 | 8.3 ± 7.5 | 91.6a | 2 | < 0.001**a |
| TNF-α(pg/ml) | 8.2 ± 2.0 | 28.1 ± 13.3 | 15.4 ± 7.0 | 90.5 | 2 | < 0.001** |
FEDN, first-episode drug-naïve; PANSS, Positive and Negative Syndrome Scale; P subscore, positive subscore; N subscore, negative subscore; G subscore, general psychopathology subscore; SANS, Scale for the Assessment of Negative Symptoms; CGI, Clinical Global Impression Scale; IL-1β, Interleukin-1β; TNF-α, tumor necrosis factor-α.
a
Refer to the results after natural logarithmic transformation was performed for IL-1β. Age of onset, education, IL-1 β and TNF-α among the three groups were compared by ANOVA.
**
P < 0.001.