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. 2018 May 11;12:92. doi: 10.3389/fnbeh.2018.00092

FIGURE 2.

FIGURE 2

Electroconvulsive seizure (ECS)-mediated hippocampal induction of Bdnf exon IV and VI requires Egr3. Exon IV (A–C) and VI (D–F) hippocampal Bdnf expression determined using qRT PCR from WT, and Egr3–/–, mice at baseline (no ECS) and 1 h after ECS. Two-way ANOVAs showed significant interactions of genotype and ECS treatment on Bdnf exon IV expression in (A) original male cohort data (p = 0.0041), (B) female cohort 1 (p = 0.0019), and (C) female cohort 2 (p = 0.0001). Two-way ANOVAs showed significant effect of treatment on Bdnf exon VI expression in original (D) male cohort (p = 0.0099), (E) female cohort 1 (p = 0.0064), and (F) female cohort 2 (p = 0.0237; n = 4–5 animals/group; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001 controlled for multiple comparisons).