Table 1.
EGR3 binding sites identified in the Bdnf promoter using TFBIND.
| ID∗1 | Score∗2 | Position∗3 | Strand∗4 | Consensus sequence∗5 | Identified sequence∗6 |
|---|---|---|---|---|---|
| V$EGR3_01 | 0.807500 | 1947 | (-) | NTGCGTGGGCGK | CCTCCCACGTCA |
| V$EGR3_01 | 0.753542 | 2881 | (-) | NTGCGTGGGCGK | ACTCGCACTCAT |
| V$EGR3_01 | 0.741042 | 3144 | (-) | NTGCGTGGGCGK | CCGCATCCGCCT |
| V$EGR3_01 | 0.901667 | 3175 | (-) | NTGCGTGGGCGK | ACGCCCGCGCAC |
| V$EGR3_01 | 0.748958 | 3179 | (-) | NTGCGTGGGCGK | CCGCGCACACGC |
| V$EGR3_01 | 0.771042 | 3181 | (-) | NTGCGTGGGCGK | GCGCACACGCGC |
| V$EGR3_01 | 0.805417 | 3187 | (-) | NTGCGTGGGCGK | ACGCGCACACAC |
| V$EGR3_01 | 0.777083 | 3296 | (-) | NTGCGTGGGCGK | CAGCCTGCGCAG |
∗1ID: transcription factor matrix ID (from TRANSFAC R.3.4). V: vertebrate. ∗2Score: degree of similarity between input sequence and registered sequence for the transcription factor binding sites at the position shown in the position column (ranging from 0 to 1, representing low–high degree of similarity). ∗3Position: location of putative EGR3 binding site in the 4000 nucleotides upstream of Bdnf transcription start site. ∗4Strand: location of EGR3 consensus sequences on + vs. - strand of DNA. ∗5Consensus sequence (fixed) of the transcription factor binding sites. K = G or T; N = any base pair. ∗6Putative EGR3 binding sequence identified by TFBIND.