Fig. 3.

Effect of GLP-1 Receptor Blockade on the Energy Expenditure Effects of OX-SR. Oxygen consumption over 12 h (A), food intake over 24 h (B), body weight change over 24 h (C), average RER over 12 h (D), and total locomotor activity over 12 h (E) following an injection of vehicle or OX-SR (40 nmol/kg), in rats single-housed in CLAMS metabolic cages. Rats previously had subcutaneous mini-osmotic pumps implanted containing saline or EX9-39. Animals had free access to standard laboratory chow throughout. N = 8. Data expressed as mean ± SEM. Statistical analysis undertaken using ordinary 2-way ANOVA with Sidak’s multiple comparison test.