Table 3.

effect of memantine compared with placebo on biomarkers level over the 12-week study period.

	Memantine ( n = 29 ) Mean ± SD		placebo (n = 29 ) Mean ± SD		p value
	Week 4	Week 12	Week 4	Week 12
IL6	3.52 ± 4.2	0.85 ± 4.83	4.72 ± 8.4	0.61 ± 3.34	0.37
TNF-α	4.87 ± 4.78	2.13 ± 4.59	2.80 ± 0.97	-0.92 ± 1.83	≤ 0.001
CRP	12.46 ± 22.39	3.07 ± 16.63	10.61 ± 11.7	2.03 ± 12.14	0.92