Figure 5.

Images of glioma stem cell (GSC) niches in human glioblastoma tumors showing an arteriole (A) and venules (V) immunohistochemically stained for CD133 (arrowhead and arrows). Reprinted with permission from (A, B) Motegi et al.⁶⁸ and (C) Hermansen et al.⁶⁷ (D) Periarteriolar GSC niche in a human glioblastoma tumor with CD133 immunostaining adjacent to the tunica adventitia of an arteriole. 1, endothelial cell; 2, tunica media; 3, tunica adventitia. Reprinted with permission from Hira et al.²¹ Bar = 30 μm (A, B, C); bar = 20 μm (D).