Figure 5.

Gene Ontology (GO) enrichment analysis in severe periodontitis and periodontitis progression. Enriched terms obtained with goseq were summarized and visualized as a scatter plot via REVIGO. Summarized GO terms related to biological processes in (A) severe periodontitis (adapted from Duran-Pinedo et al. 2014) and (B) health (adapted from Duran-Pinedo et al. 2014). GO enrichment analysis comparison of baselines from progressing and nonprogressing sites: Summarized GO terms related to biological processes in baselines of (C) progressing and (D) nonprogressing sites (adapted from Yost et al. 2015). In red are activities that have been associated with pathogenesis in periodontitis. Circle size is proportional to the frequency of the GO term, whereas color indicates the log10 P value (red higher, blue lower).