Figure 5.

Models showing heparin binding in CXCL1, CXCL5, and CXCL8. Panels A and B show the non-overlapping heparin-binding surfaces (defined as α- and β-domains) in CXCL1. Heparin-binding residues from both monomers are highlighted in light and dark blue. Panel C shows heparin binding to both the domains. Panel D shows the heparin-binding surface in CXCL5. The second monomer of the dimer is shown in black for clarity. Panel E shows the binding of heparin to each of the two monomers. Panels F and G show two of the heparin-binding surfaces observed for CXCL8.