Figure 3.

Autoregressive models with contemporaneous and lagged b paths and simplex models with contemporaneous and lagged covariances using PACE example time points.

M₀, M₁₂, M₂₄, M₅₂: mediator measurements taken at baseline, 12 weeks, 24 weeks and 52 weeks post-randomisation. Y₀, Y₁₂, Y₂₄, Y₅₂: outcome measurements taken at the same time points. FM₀: latent true mediator score at baseline, FM₁₂: latent true mediator score at 12 weeks, FM₂₄: latent true mediator score at 24 weeks, FM₅₂ = latent true mediator score at 52 weeks, FY₀, FY₁₂, FY₂₄, FY₅₂ = latent true outcome scores as described for the mediator.