Table 2.
Mood assessment and standard tests of intelligence and memory results
| Mutation carriers | Non-carriers | p value | |
|---|---|---|---|
| HADS anxiety score (out of 21) | 6·0 (3·0–9·0) | 4·5 (4·0–7·0) | 0·47 |
| HADS depression score (out of 21) | 2·0 (0·0–2·0) | 1·0 (0·0–2·0) | 0·59 |
| Mini mental state examination (out of 30) | 29·0 (29·0–30·0) | 29·5 (29·0–30·0) | >0·05 |
| WASI verbal IQ | 106 (91–108) | 103 (95–103) | 0·37 |
| WASI performance IQ | 104 (100–116) | 119 (106–121) | 0·03 |
| Recognition Memory Test words (out of 50) | 49·0 (49·0–50·0) | 48·0 (46·0–50·0) | <0·05 |
| Recognition Memory Test faces (out of 50) | 45·0 (43·0–48·0) | 45·5 (44·0–47·0) | >0·05 |
| Camden paired associate learning (out of 24) | 19·0 (16·0–22·0) | 19·0 (17·0–22·0) | >0·05 |
Data are median (IQR). p values are shown for variables that satisfied the assumptions of the linear regression model. For other variables, parametric assumptions were not met and therefore p<0·05 or p>0·05 was inferred from bootstrapped 95% CIs. For HADS anxiety, HADS depression, mini mental state examination, Recognition Memory Test faces, Recognition Memory Test words, and Camden paired associate learning, p values reflect group differences after adjusting for age (years) and IQ (WASI total score). Analysis of WASI performance IQ and WASI verbal IQ was unadjusted, as these measures were corrected for age. HADS=Hospital Anxiety and Depression Scale. WASI=Wechsler Abbreviated Scale of Intelligence.