Table 3.
Long-term forgetting assessment results
| Mutation carriers | Non-carriers | p value | Difference in mean | 95% CI | |
|---|---|---|---|---|---|
| Learning | |||||
| List learning trials | 5·0 (4·0–6·0) | 4·0 (4·0–6·0) | >0·05 | −0·06 | −1·01 to 0·97 |
| Story learning trials | 3·0 (2·0–3·0) | 2·0 (2·0–3·0) | >0·05 | 0·07 | −0·50 to 0·82 |
| List learning score | 80·0% (80·0–86·7) | 86·7% (80·0–93·3) | >0·05 | −1·77 | −7·01 to 2·49 |
| Story learning score | 87·5% (83·3–91·1) | 90·5% (87·5–94·6) | 0·67 | −0·60 | −3·50 to 2·30 |
| Figure learning score | 100·0% (97·4–100·0) | 100·0% (99·3–100·0) | >0·05 | 6·39 | −4·00 to 15·21 |
| 30-min retention | |||||
| List 30-min recall | 80·0% (73·3–80·0) | 80·0% (73·3–86·7) | 0·85 | 0·66 | −6·52 to 7·84 |
| Story 30-min recall | 83·3% (80·0–87·5) | 87·9% (80·4–91·1) | 0·76 | −0·74 | −5·77 to 4·29 |
| Figure 30-min recall | 92·5% (72·4–97·4) | 88·4% (72·4–96·7) | 0·34 | 5·72 | −6·55 to 17·98 |
| 7-day retention (seconday outcomes) | |||||
| 7-day list recall | 26·7% (20·0–46·7) | 56·7% (46·7–66·7) | 0·0021 | −24·55 | −39·01 to −10·10 |
| 7-day story recall | 56·7% (50·0–68·3) | 79·3% (71·4–83·9) | 0·0031 | −17·97 | −29·06 to −6·88 |
| 7-day figure recall | 59·2% (48·8–73·7) | 74·3% (62·5–83·2) | 0·22 | −8·67 | −22·91 to 5·57 |
| 7-day list recognition | 93·3% (86·7–100·0) | 100·0% (100·0–100·0) | <0·01 | −5·80 | −9·96 to −2·47 |
| 7-day story recognition | 91·7% (91·7–100·0) | 100·0% (100·0–100·0) | <0·01 | −6·84 | −10·94 to −3·37 |
| 7-day figure recognition | 75·0% (75·0–100·0) | 100·0% (100·0–100·0) | <0·01 | −17·61 | −27·68 to −7·72 |
| 7-day retention (primary outcome) | |||||
| List 7-day recall divided by 30-min recall | 36·4 (30·0–58·3) | 71·8 (55·6–81·8) | 0·0002 | −30·94 | −45·16 to −16·73 |
| Story 7-day recall divided by 30-min recall | 66·7 (58·8–81·3) | 92·2 (81·1–95·7) | 0·0048 | −20·10 | −33·28 to −6·91 |
| Figure 7-day recall divided by 30-min recall | 70·3 (63·2–82·1) | 87·6 (76·9–96·4) | 0·012 | −15·41 | −26·88 to −3·93 |
Data are uncorrected group medians (IQR). Exact p values are shown for variables that satisfied the assumptions of the linear regression model. For other variables, parametric assumptions were not met and therefore p<0·05 or p>0·05 and p<0·01 or p>0·01 was inferred from bootstrapped 95% and 99% CIs. Differences in means, 95% CIs, and p values are adjusted for age, intelligence quotient (Wechsler Abbreviated Scale of Intelligence total score), and test set. Robust standard errors accounted for clustering of participants within families. Secondary outcome measures for each of the three tests were 7-day recall and recognition scores, with the primary outcome measure being 7-day recall divided by 30-min recall. For the list and story, learning score refers to the score from the final learning trial.