Table 1.

Model settings for simulations.

	Linear adjustment					Allometry adjustment					Maturation adjustment
Doses (mg/kg)	25	35	45	55	70	35	50	65	80	100	30	45	55	70	85
WMs for toxicity
WM1	0.07	0.13	0.21	0.33	0.55	0.13	0.27	0.48	0.70	0.88	0.10	0.21	0.33	0.55	0.76
WM2	0.13	0.21	0.33	0.55	0.78	0.27	0.48	0.70	0.88	0.94	0.21	0.33	0.55	0.76	0.88
WM3	0.04	0.07	0.13	0.21	0.33	0.06	0.13	0.27	0.48	0.70	0.05	0.10	0.21	0.33	0.55
WM for efficacy	0.05	0.20	0.43	0.64	0.79	0.05	0.20	0.43	0.64	0.79	0.05	0.20	0.43	0.64	0.79
Option ESS
${\pi }_{\mathit{ESS}}(a)$	$\mathcal{N}(-0.31,0.36)$					$\mathcal{N}(-0.38,0.50)$					$\mathcal{N}(-0.34,0.42)$
Option least informative prior
${\pi }_{\mathit{LIP}}(a)$	$\mathcal{N}(-0.31,0.46)$					$\mathcal{N}(-0.38,3.13)$					$\mathcal{N}(-0.34,1.46)$
${\pi }_{\mathit{NIP}}(a)$	$\mathcal{N}(-0.31,4.33)$					$\mathcal{N}(-0.38,15.24)$					$\mathcal{N}(-0.34,8.88)$
$\pi (b)$	$\mathcal{N}(0,1.34)$					$\mathcal{N}(0,1.34)$					$\mathcal{N}(0,1.34)$

AP_ESS-bCMR uses adaptive prior from ${\pi }_{\mathit{ESS}}(a)\sim \mathcal{N}({\mu }_a,{\sigma }_{a,\mathit{ESS}}^2)$ to ${\pi }_{\mathit{NIP}}(a)\sim \mathcal{N}({\mu }_a,{\sigma }_{a,\mathit{NIP}}^2)$ and AP_LIP-bCRM uses adaptive prior from ${\pi }_{\mathit{LIP}}(a)\sim \mathcal{N}({\mu }_a,{\sigma }_{a,\mathit{LIP}}^2)$ to ${\pi }_{\mathit{NIP}}(a)$.