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. 2018 May 11;9:813. doi: 10.3389/fmicb.2018.00813

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Copyright © 2018 Eijkelkamp, Begg, Pederick, Trapetti, Gregory, Whittall, Paton and McDevitt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examination of arachidonic acid as an anti-pneumococcal agent. (A) Examination of plasma fatty acids before and after infection with S. pneumoniae strain D39. (B) Examination of pneumococcal growth upon treatment with AA at 62.5, 125, or 250 μM. The OD₆₀₀ was determined every 30 min. (C) Intracellular survival of pneumococci within THP-1 derived macrophages treated with 5 μM AA by comparison with untreated macrophages. All data are the mean of at least biological triplicates (±SEM) and where error bars are not visible this is due to occlusion by the shown symbols. Statistical analyses were performed using a Student's t-test (^*p < 0.05).