Table 1.

Terminology for statin-associated myopathy^*

Term	Laboratory characteristics	Clinical characteristics
Myalgia	CK ≤ ULN	Muscle ache or weakness
Myositis	CK > ULN	Muscle ache or weakness
Rhabdomyolysis	CK > 10× ULN	Muscle ache or weakness ± myoglobinuria
Mild (grade 1) hyperCKemia	CK > ULN but ≤ 5× ULN	May or may not have myositis
Mild (grade 2) hyperCKemia	CK > 5× ULN but ≤ 10× ULN	May or may not have myositis
Moderate hyperCKemia	CK > 10× ULN but ≤ 50× ULN	May or may not have rhabdomyolysis
Severe hyperCKemia	CK >50× ULN	May or may not have rhabdomyolysis

^*Adapted from Mancini et al.³ with permission from Elsevier. CK, creatine kinase; ULN, upper limit of normal.