Table 2.
Compound(s) | Interaction Score | Consensus Score | Approved Indication | Mode of Action |
---|---|---|---|---|
Niclosamide * | 1.897 | 3 | helminthic infestation | inhibits parasite metabolism |
Sertraline * | 1.897 | 1 | depression, anxiety | selective serotonin receptor inhibitor |
Clomifene * | 1.897 | 1 | anovulation, oligoovulation | selective estrogen receptor modulator |
Alverine | 1.897 | 1 | gastrointestinal muscle spasms | parasympathetic nervous system modulator |
Aprindine | 1.897 | 1 | cardiac arrhythmia | sodium channel inhibitor |
Mebendazole * | 1.897 | 1 | helminthic infestation | tubulin destabilizer |
Salmeterol | 1.890 | 2 | asthma | beta 2 adrenergic receptor agonist |
Topotecan | 1.823 | 1 | ovarian and lung cancers | DNA topoisomerase I inhibitor |
Deslanoside * | 1.377 | 10 | cardiac arrhythmia | sodium-potassium channel blocker |
Propafenone | 1.298 | 10 | cardiac arrhythmia | sodium channel blocker |
Digoxin * | 1.067 | 1 | cardiac arrhythmia | sodium-potassium channel blocker |
Proglumetacin | 1.058 | 1 | non-steroidal anti-inflammatory drug | cyclooxygenase-1 inhibitor |
Posaconazole | 1.023 | 3 | fungal infection (aspergillus and candida) | membrane bound enzyme inhibitor |
Raloxifene * | 0.843 | 2 | osteoporosis and breast cancer prevention | selective estrogen receptor modulator |
Clarithromycin | 0.741 | 2 | bacterial infections | protein synthesis inhibitor |
Clemastine * | 0.741 | 1 | allergies | H1 histamine receptor inhibitor |
Colchicine | 0.741 | 1 | gout, pericarditis | microtubule inhibitor |
Tamoxifen * | 0.741 | 1 | estrogen receptor positive breast cancer | Selective estrogen receptor modulator |
Thiothixene | 0.741 | 1 | psychotic disorders, e.g., schizophrenia | dopamine antagonist |
Daunorubicin | 0.714 | 1 | hematologic dyscrasia (acute lymphocytic leukemia, acute myeloid leukemia) | DNA topoisomerase II inhibitor |
Dronedarone | 0.722 | 1 | cardiac arrhythmia | potassium channel blocker |
Vincristine | 0.707 | 1 | hematologic dyscrasia (acute lymphocytic leukemia, acute myeloid leukemia) | microtubule inhibitor |
* Drugs also identified by Johansen et al. [28].