Table 3.
Compound(s) | Interaction Score | Consensus Score | Approved Indication | Mode of Action |
---|---|---|---|---|
Niclosamide * | 1.897 | 3 | helminthic infestation | inhibits parasite metabolism |
Quinestrol | 1.897 | 3 | hormone replacement therapy | synthetic steroidal estrogen receptor agonist |
Sertraline * | 1.897 | 1 | depression, anxiety | selective serotonin receptor inhibitor |
Clomifene * | 1.897 | 1 | anovulation, oligoovulation | selective estrogen receptor modulator |
Propoxyphene | 1.897 | 1 | mild to moderate pain | opiate receptor binder |
Atovaquone | 1.897 | 1 | pneumocystis Pneumonia | dihydroorotate dehydrogenase inhibitor |
Azelastine | 1.897 | 1 | allergic rhinitis | H1 histamine receptor inhibitor |
Danazol | 1.897 | 1 | endometriosis | androgen receptor competitive inhibitor |
Mebendazole * | 1.897 | 1 | helminthic infestation | tubulin destabilizer |
Hydroxyprogesterone | 1.823 | 2 | preterm labor | steroidal progesterone receptor agonist |
Deslanoside * | 1.377 | 10 | cardiac arrhythmia | sodium-potassium channel blocker |
Digoxin * | 1.067 | 1 | cardiac arrhythmia | sodium-potassium channel blocker |
Ritonavir | 1.057 | 2 | HIV infection | protease inhibitor |
Raloxifene * | 0.843 | 2 | osteoporosis and breast cancer prevention | selective estrogen receptor modulator |
Ciclesonide | 0.843 | 1 | asthma, allergic rhinitis | glucocorticoid receptor agonist |
Clemastine * | 0.741 | 1 | allergies | H1 histamine receptor inhibitor |
Podofilox | 0.741 | 1 | skin warts caused by Human papilloma virus | tubulin polymerization inhibitor |
Tamoxifen * | 0.741 | 1 | estrogen receptor + breast cancer | selective estrogen receptor modulator |
Desloratadine | 0.741 | 1 | allergies | H1 histamine receptor inhibitor |
Methdilazine | 0.741 | 1 | allergy symptoms, antiemetic | H1 histamine receptor antagonist |
Chlorcyclizine | 0.741 | 1 | allergy symptoms, antiemetic | H1 histamine receptor antagonist |
Azacitidine | 0.712 | 1 | myelodysplastic syndrome | DNA methyl transferase inhibitor |
Terconazole | 0.711 | 1 | fungal infection | ERG11/CYP51 inhibitor |
Bromocriptine | 0.707 | 1 | pituitary tumors, Parkinson’s disease | dopamine receptor agonist |
* Drugs also identified by Kouznetsova et al. [27].